Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe.
Identifieur interne : 000903 ( Main/Exploration ); précédent : 000902; suivant : 000904Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe.
Auteurs : Umberto Malapelle [Italie] ; Pasquale Pisapia [Italie] ; Antonino Iaccarino [Italie] ; Massimo Barberis [Italie] ; Claudio Bellevicine [Italie] ; Hans Brunnström [Suède] ; Dario De Biase [Italie] ; Giovanna De Maglio [Italie] ; Kajsa Ericson Lindquist [Suède] ; Matteo Fassan [Italie] ; Gabriella Fontanini [Italie] ; Elisa Gruppioni [Italie] ; Paul Hofman [France] ; Sabine Merkelbach-Bruse [Allemagne] ; Miguel A. Molina Vila [Espagne] ; Anaïs Pujals [France] ; Ida Rapa [Italie] ; Luisella Righi [Italie] ; Rafael Rosell [Espagne] ; Oliver Schildgen [Allemagne] ; Verena Schildgen [Allemagne] ; Fernando C. Schmitt [Portugal] ; Giovanni Tallini [Italie] ; Sara Vander Borght [Belgique] ; Elena Vigliar [Italie] ; Marco Volante [Italie] ; Svenja Wagener-Ryczek [Allemagne] ; Birgit Weynand [Belgique] ; Giancarlo Troncone [Italie]Source :
- Journal of clinical pathology [ 1472-4146 ] ; 2020.
Abstract
AIMS
Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak.
METHODS
Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time.
RESULTS
In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing.
CONCLUSIONS
The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
DOI: 10.1136/jclinpath-2020-206957
PubMed: 32737190
PubMed Central: PMC7397978
Affiliations:
- Allemagne, Belgique, Espagne, France, Italie, Portugal, Suède
- Catalogne, Lombardie, Piémont, Provence-Alpes-Côte d'Azur, Toscane, Île-de-France
- Barcelone, Créteil, Milan, Nice, Pise, Turin
- Université de Pise
Links toward previous steps (curation, corpus...)
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Pathology, University Hospital of Udine, Udine, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, University Hospital of Udine, Udine</wicri:regionArea><wicri:noRegion>Udine</wicri:noRegion></affiliation></author><author><name sortKey="Ericson Lindquist, Kajsa" sort="Ericson Lindquist, Kajsa" uniqKey="Ericson Lindquist K" first="Kajsa" last="Ericson Lindquist">Kajsa Ericson Lindquist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Fassan, Matteo" sort="Fassan, Matteo" uniqKey="Fassan M" first="Matteo" last="Fassan">Matteo Fassan</name><affiliation wicri:level="1"><nlm:affiliation>Surgical Pathology Unit, Department of Medicine, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Surgical Pathology Unit, Department of Medicine, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Fontanini, Gabriella" sort="Fontanini, Gabriella" uniqKey="Fontanini G" first="Gabriella" last="Fontanini">Gabriella Fontanini</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical, Medical, and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgical, Medical, and Molecular Pathology and Critical Area, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Gruppioni, Elisa" sort="Gruppioni, Elisa" uniqKey="Gruppioni E" first="Elisa" last="Gruppioni">Elisa Gruppioni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Bologna Medical Center, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, University of Bologna Medical Center, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Paul" sort="Hofman, Paul" uniqKey="Hofman P" first="Paul" last="Hofman">Paul Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Pathology, INSERM, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pathology, INSERM, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Merkelbach Bruse, Sabine" sort="Merkelbach Bruse, Sabine" uniqKey="Merkelbach Bruse S" first="Sabine" last="Merkelbach-Bruse">Sabine Merkelbach-Bruse</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Molina Vila, Miguel A" sort="Molina Vila, Miguel A" uniqKey="Molina Vila M" first="Miguel A" last="Molina Vila">Miguel A. Molina Vila</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Oncology, Pangaea Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Oncology, Pangaea Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pujals, Anais" sort="Pujals, Anais" uniqKey="Pujals A" first="Anaïs" last="Pujals">Anaïs Pujals</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, CHU Henri Mondor, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, CHU Henri Mondor, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Rapa, Ida" sort="Rapa, Ida" uniqKey="Rapa I" first="Ida" last="Rapa">Ida Rapa</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Unit, Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Unit, Department of Oncology, San Luigi Gonzaga Hospital, Orbassano</wicri:regionArea><wicri:noRegion>Orbassano</wicri:noRegion></affiliation></author><author><name sortKey="Righi, Luisella" sort="Righi, Luisella" uniqKey="Righi L" first="Luisella" last="Righi">Luisella Righi</name><affiliation wicri:level="3"><nlm:affiliation>Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Unit, Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Rosell, Rafael" sort="Rosell, Rafael" uniqKey="Rosell R" first="Rafael" last="Rosell">Rafael Rosell</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Biology and Precision Medicine Program, Catalan Institute of Oncology; Germans Trias i Pujol Health Sciences Institute and Hospital Badalona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Biology and Precision Medicine Program, Catalan Institute of Oncology; Germans Trias i Pujol Health Sciences Institute and Hospital Badalona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Schildgen, Oliver" sort="Schildgen, Oliver" uniqKey="Schildgen O" first="Oliver" last="Schildgen">Oliver Schildgen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Schildgen, Verena" sort="Schildgen, Verena" uniqKey="Schildgen V" first="Verena" last="Schildgen">Verena Schildgen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Schmitt, Fernando C" sort="Schmitt, Fernando C" uniqKey="Schmitt F" first="Fernando C" last="Schmitt">Fernando C. Schmitt</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, IPATIMUP and Medical Faculty of Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pathology, IPATIMUP and Medical Faculty of Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Tallini, Giovanni" sort="Tallini, Giovanni" uniqKey="Tallini G" first="Giovanni" last="Tallini">Giovanni Tallini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Bologna Medical Center, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, University of Bologna Medical Center, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Vander Borght, Sara" sort="Vander Borght, Sara" uniqKey="Vander Borght S" first="Sara" last="Vander Borght">Sara Vander Borght</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospitals Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Vigliar, Elena" sort="Vigliar, Elena" uniqKey="Vigliar E" first="Elena" last="Vigliar">Elena Vigliar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Volante, Marco" sort="Volante, Marco" uniqKey="Volante M" first="Marco" last="Volante">Marco Volante</name><affiliation wicri:level="3"><nlm:affiliation>Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Unit, Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Wagener Ryczek, Svenja" sort="Wagener Ryczek, Svenja" uniqKey="Wagener Ryczek S" first="Svenja" last="Wagener-Ryczek">Svenja Wagener-Ryczek</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Weynand, Birgit" sort="Weynand, Birgit" uniqKey="Weynand B" first="Birgit" last="Weynand">Birgit Weynand</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospitals Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Troncone, Giancarlo" sort="Troncone, Giancarlo" uniqKey="Troncone G" first="Giancarlo" last="Troncone">Giancarlo Troncone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy giancarlo.troncone@unina.it.</nlm:affiliation><country wicri:rule="url">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32737190</idno><idno type="pmid">32737190</idno><idno type="doi">10.1136/jclinpath-2020-206957</idno><idno type="pmc">PMC7397978</idno><idno type="wicri:Area/Main/Corpus">000766</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000766</idno><idno type="wicri:Area/Main/Curation">000766</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000766</idno><idno type="wicri:Area/Main/Exploration">000766</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe.</title><author><name sortKey="Malapelle, Umberto" sort="Malapelle, Umberto" uniqKey="Malapelle U" first="Umberto" last="Malapelle">Umberto Malapelle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Pisapia, Pasquale" sort="Pisapia, Pasquale" uniqKey="Pisapia P" first="Pasquale" last="Pisapia">Pasquale Pisapia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Iaccarino, Antonino" sort="Iaccarino, Antonino" uniqKey="Iaccarino A" first="Antonino" last="Iaccarino">Antonino Iaccarino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Barberis, Massimo" sort="Barberis, Massimo" uniqKey="Barberis M" first="Massimo" last="Barberis">Massimo Barberis</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Pathology, European Institute of Oncology IRCCS, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bellevicine, Claudio" sort="Bellevicine, Claudio" uniqKey="Bellevicine C" first="Claudio" last="Bellevicine">Claudio Bellevicine</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Brunnstrom, Hans" sort="Brunnstrom, Hans" uniqKey="Brunnstrom H" first="Hans" last="Brunnström">Hans Brunnström</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="De Biase, Dario" sort="De Biase, Dario" uniqKey="De Biase D" first="Dario" last="De Biase">Dario De Biase</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacy and Biotechnology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="De Maglio, Giovanna" sort="De Maglio, Giovanna" uniqKey="De Maglio G" first="Giovanna" last="De Maglio">Giovanna De Maglio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospital of Udine, Udine, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, University Hospital of Udine, Udine</wicri:regionArea><wicri:noRegion>Udine</wicri:noRegion></affiliation></author><author><name sortKey="Ericson Lindquist, Kajsa" sort="Ericson Lindquist, Kajsa" uniqKey="Ericson Lindquist K" first="Kajsa" last="Ericson Lindquist">Kajsa Ericson Lindquist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Fassan, Matteo" sort="Fassan, Matteo" uniqKey="Fassan M" first="Matteo" last="Fassan">Matteo Fassan</name><affiliation wicri:level="1"><nlm:affiliation>Surgical Pathology Unit, Department of Medicine, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Surgical Pathology Unit, Department of Medicine, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Fontanini, Gabriella" sort="Fontanini, Gabriella" uniqKey="Fontanini G" first="Gabriella" last="Fontanini">Gabriella Fontanini</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical, Medical, and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgical, Medical, and Molecular Pathology and Critical Area, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Gruppioni, Elisa" sort="Gruppioni, Elisa" uniqKey="Gruppioni E" first="Elisa" last="Gruppioni">Elisa Gruppioni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Bologna Medical Center, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, University of Bologna Medical Center, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Paul" sort="Hofman, Paul" uniqKey="Hofman P" first="Paul" last="Hofman">Paul Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Pathology, INSERM, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pathology, INSERM, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Merkelbach Bruse, Sabine" sort="Merkelbach Bruse, Sabine" uniqKey="Merkelbach Bruse S" first="Sabine" last="Merkelbach-Bruse">Sabine Merkelbach-Bruse</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Molina Vila, Miguel A" sort="Molina Vila, Miguel A" uniqKey="Molina Vila M" first="Miguel A" last="Molina Vila">Miguel A. Molina Vila</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Oncology, Pangaea Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Oncology, Pangaea Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pujals, Anais" sort="Pujals, Anais" uniqKey="Pujals A" first="Anaïs" last="Pujals">Anaïs Pujals</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, CHU Henri Mondor, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, CHU Henri Mondor, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Rapa, Ida" sort="Rapa, Ida" uniqKey="Rapa I" first="Ida" last="Rapa">Ida Rapa</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Unit, Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Unit, Department of Oncology, San Luigi Gonzaga Hospital, Orbassano</wicri:regionArea><wicri:noRegion>Orbassano</wicri:noRegion></affiliation></author><author><name sortKey="Righi, Luisella" sort="Righi, Luisella" uniqKey="Righi L" first="Luisella" last="Righi">Luisella Righi</name><affiliation wicri:level="3"><nlm:affiliation>Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Unit, Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Rosell, Rafael" sort="Rosell, Rafael" uniqKey="Rosell R" first="Rafael" last="Rosell">Rafael Rosell</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Biology and Precision Medicine Program, Catalan Institute of Oncology; Germans Trias i Pujol Health Sciences Institute and Hospital Badalona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Biology and Precision Medicine Program, Catalan Institute of Oncology; Germans Trias i Pujol Health Sciences Institute and Hospital Badalona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Schildgen, Oliver" sort="Schildgen, Oliver" uniqKey="Schildgen O" first="Oliver" last="Schildgen">Oliver Schildgen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Schildgen, Verena" sort="Schildgen, Verena" uniqKey="Schildgen V" first="Verena" last="Schildgen">Verena Schildgen</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Schmitt, Fernando C" sort="Schmitt, Fernando C" uniqKey="Schmitt F" first="Fernando C" last="Schmitt">Fernando C. Schmitt</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, IPATIMUP and Medical Faculty of Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pathology, IPATIMUP and Medical Faculty of Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Tallini, Giovanni" sort="Tallini, Giovanni" uniqKey="Tallini G" first="Giovanni" last="Tallini">Giovanni Tallini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Bologna Medical Center, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, University of Bologna Medical Center, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Vander Borght, Sara" sort="Vander Borght, Sara" uniqKey="Vander Borght S" first="Sara" last="Vander Borght">Sara Vander Borght</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospitals Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Vigliar, Elena" sort="Vigliar, Elena" uniqKey="Vigliar E" first="Elena" last="Vigliar">Elena Vigliar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Volante, Marco" sort="Volante, Marco" uniqKey="Volante M" first="Marco" last="Volante">Marco Volante</name><affiliation wicri:level="3"><nlm:affiliation>Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Unit, Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Wagener Ryczek, Svenja" sort="Wagener Ryczek, Svenja" uniqKey="Wagener Ryczek S" first="Svenja" last="Wagener-Ryczek">Svenja Wagener-Ryczek</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pathology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Weynand, Birgit" sort="Weynand, Birgit" uniqKey="Weynand B" first="Birgit" last="Weynand">Birgit Weynand</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospitals Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Troncone, Giancarlo" sort="Troncone, Giancarlo" uniqKey="Troncone G" first="Giancarlo" last="Troncone">Giancarlo Troncone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy giancarlo.troncone@unina.it.</nlm:affiliation><country wicri:rule="url">Italie</country><wicri:regionArea>Department of Public Health, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of clinical pathology</title><idno type="eISSN">1472-4146</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIMS</b></p><p>Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32737190</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1472-4146</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>31</Day></PubDate></JournalIssue><Title>Journal of clinical pathology</Title><ISOAbbreviation>J. Clin. Pathol.</ISOAbbreviation></Journal><ArticleTitle>Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">jclinpath-2020-206957</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1136/jclinpath-2020-206957</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.</AbstractText><CopyrightInformation>© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Malapelle</LastName><ForeName>Umberto</ForeName><Initials>U</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3211-9957</Identifier><AffiliationInfo><Affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Pisapia</LastName><ForeName>Pasquale</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6429-0620</Identifier><AffiliationInfo><Affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Iaccarino</LastName><ForeName>Antonino</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barberis</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0943-4804</Identifier><AffiliationInfo><Affiliation>Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellevicine</LastName><ForeName>Claudio</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brunnström</LastName><ForeName>Hans</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Biase</LastName><ForeName>Dario</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0609-8817</Identifier><AffiliationInfo><Affiliation>Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Maglio</LastName><ForeName>Giovanna</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital of Udine, Udine, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ericson Lindquist</LastName><ForeName>Kajsa</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fassan</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Surgical Pathology Unit, Department of Medicine, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fontanini</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Surgical, Medical, and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruppioni</LastName><ForeName>Elisa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Bologna Medical Center, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Paul</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-0431-9353</Identifier><AffiliationInfo><Affiliation>Pathology, INSERM, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merkelbach-Bruse</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Pathology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molina Vila</LastName><ForeName>Miguel A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Laboratory of Oncology, Pangaea Oncology, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pujals</LastName><ForeName>Anaïs</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3452-7420</Identifier><AffiliationInfo><Affiliation>Department of Pathology, CHU Henri Mondor, Creteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rapa</LastName><ForeName>Ida</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Pathology Unit, Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Righi</LastName><ForeName>Luisella</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosell</LastName><ForeName>Rafael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cancer Biology and Precision Medicine Program, Catalan Institute of Oncology; Germans Trias i Pujol Health Sciences Institute and Hospital Badalona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schildgen</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schildgen</LastName><ForeName>Verena</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Hospital of the Private University Witten/Herdecke, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Fernando C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Pathology, IPATIMUP and Medical Faculty of Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tallini</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Bologna Medical Center, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vander Borght</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospitals Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vigliar</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volante</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagener-Ryczek</LastName><ForeName>Svenja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Pathology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weynand</LastName><ForeName>Birgit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospitals Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Troncone</LastName><ForeName>Giancarlo</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1630-5805</Identifier><AffiliationInfo><Affiliation>Department of Public Health, University of Naples Federico II, Naples, Italy giancarlo.troncone@unina.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Clin Pathol</MedlineTA><NlmUniqueID>0376601</NlmUniqueID><ISSNLinking>0021-9746</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">biomarkers</Keyword><Keyword MajorTopicYN="N">lung neoplasms</Keyword><Keyword MajorTopicYN="N">molecular</Keyword><Keyword MajorTopicYN="N">molecular biology</Keyword><Keyword MajorTopicYN="N">pathology</Keyword><Keyword MajorTopicYN="N">tumour</Keyword></KeywordList><CoiStatement>Competing interests: UM reports personal fees (as speaker bureau or advisor) from Boehringer Ingelheim, AstraZeneca, Roche, MSD, Amgen, Merck and BMS. GTr reports personal fees (as speaker bureau or advisor) from Roche, MSD and Pfizer.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32737190</ArticleId><ArticleId 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